High Shear Mixer Granulator — High-Performance Wet Granulation Solutio

igh Shear Mixer Granulator — High-Performance Wet Granulation Solution for Pharmaceutical Manufacturing

A High Shear Mixer Granulator (also known as a High Shear Mixer, mixer granulator, or high shear mixing machine) is essential equipment for wet granulation in pharmaceutical solid dosage manufacturing. It rapidly blends powders and distributes liquid binders to produce uniform, flowable, and highly compressible granules, enabling stable tablet and capsule production and improving both product quality and production efficiency.

 

Wet Granulation for Challenging Formulations

 

Unlike roller compactors used for dry granulation, the High Shear Mixer Granulator is engineered specifically for wet granulation using liquid binders. Wet granulation is widely preferred when formulations require higher flowability, cohesion, and content uniformity, especially in:

Poor-flow or low-density powders Low-dose API formulations Direct compression–challenging materials

 

Process Principle of High Shear Granulation

Typical process steps include:

Dry Mixing of powders Binder Addition & Wet Massing Agglomeration & Granule Growth

The high-speed impeller fluidizes and compresses the powder bed, while the chopper cuts wet lumps into smaller agglomerates, forming granules with the target particle size distribution and density.

 

Key Advantages

 

Short batch time & high throughput enabled by strong shear force and rapid granule formation Produces uniform granules with narrow particle size distribution Improved flowability and compressibility, ideal for high-speed tablet presses & capsule fillers Precise control of impeller speed, chopper speed, and binder feed rate ensures consistent batch-to-batch quality Scalable from R&D to pilot and commercial production

 

Features of PTK High Shear Mixer Granulator

PTK’s High Shear Mixer Granulator integrates mixing and wet granulation in a bottom-driven single-pot system, reducing contamination risk and improving processing efficiency.

Main Features

Full recipe & product data management via HMI Batch reports & data analytics for validation and compliance (GMP / 21 CFR Part 11) Liftable impeller and optional automatic lid lifting for improved accessibility and easier cleaning Optional features: WIP cleaning, jacketed bowl, temperature & pressure monitoring, and 12-bar pressure-tested structure for hygienic and safe production environments