High Shear Mixer for Pharmaceutical Wet Granulation
A High Shear Mixer is a core piece of pharmaceutical equipment used exclusively for wet granulation in solid dosage manufacturing. It rapidly mixes powders and uniformly disperses liquid binders to produce dense, free-flowing granules with excellent compressibility.
By applying strong mechanical agitation and shear force through an impeller and chopper, High Shear Mixers improve content uniformity, flowability, and tabletability—enabling stable and reproducible tablet and capsule production.
How a High Shear Mixer Works
A typical High Shear wet granulation process consists of three stages: mixing, wetting, and granule formation. The main impeller fluidizes and homogenizes the powder bed, while liquid binders are added to form liquid bridges between particles.
The chopper applies localized shear to control granule growth and particle size distribution. Key parameters such as impeller speed, chopper speed, binder addition rate, and processing time directly affect granule density and flow properties.
Why High Shear Mixers Are Essential in Pharmaceutical Manufacturing
High Shear Mixers are especially effective for formulations requiring precise content uniformity, including low-dose and high-potency APIs. Their ability to tightly control wet granulation conditions ensures excellent batch-to-batch reproducibility and process stability.
Lab-Scale High Shear Mixer: PM-C Lab Series
The PM-C Lab Series High Shear Mixer is designed for formulation development and small-batch R&D applications. Its interchangeable bowl system supports flexible batch sizing, while HMI-based parameter storage enables efficient process optimization and early-stage scale-up.
Pilot-Scale High Shear Mixer: PM-Pilot Series
The PM-Pilot High Shear Mixer bridges lab-scale development and full-scale production. It allows wet granulation parameters established during R&D to be directly applied to pilot batches, significantly reducing scale-up risk while maintaining production-representative vessel geometry.
Production High Shear Mixer: PM-1100~ Series
The PM-1100~ Series is a high-capacity, fully automated High Shear Mixer designed for medium- to large-scale pharmaceutical production. Features include recipe management, batch reporting, WIP cleaning, jacketed vessels, pressure monitoring up to 12 bar, and 21 CFR Part 11–compliant HMI control.
Key Considerations When Selecting a High Shear Mixer
Selecting the right High Shear Mixer requires evaluation of batch size, formulation characteristics, scale-up strategy, cleaning and validation requirements, and data integrity. The PTK PM Series—PM-C Lab, PM-Pilot, and PM-1100~—provides a unified wet granulation platform from R&D through commercial production.
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