High-Containment Rotary Tablet Press

High-Containment Rotary Tablet Press for HPAPI
PR-1500H with WIP (Wash-In-Place)

The PR-1500H is a high-containment rotary tablet press specifically engineered for the safe handling of highly potent active pharmaceutical ingredients (HPAPI) and toxic powders.

By locally isolating the critical turret zone, where dust generation primarily occurs, the PR-1500H effectively prevents powder dispersion while prioritizing operator safety and regulatory compliance.

1. Core Containment Technology: Zone-Limited Isolation

Instead of enclosing the entire machine, the PR-1500H applies targeted containment to the turret zone, delivering an efficient and practical high-containment solution.

Compact Containment Chamber

Only the tablet compression area is enclosed, preventing dust from spreading into drive components or the surrounding environment. This localized design reduces cleaning scope and significantly improves maintenance efficiency.

Fully Sealed Structure

All doors, access points, and interfaces are equipped with high-performance sealing systems to strictly control any potential leakage of fine powders during operation.

2. Operator Protection Through An Advanced WIP System

The PR-1500H minimizes operator exposure after production through a fully integrated Wash-In-Place (WIP) system.

Safe Deactivation Process

Safe Deactivation is the most critical safety step performed before opening the containment chamber. Cleaning liquid is sprayed inside the sealed chamber to pre-wash and remove residual fine powders, effectively eliminating the risk of dust dispersion when the equipment is opened.

Automated WIP Nozzle System

Multiple dedicated nozzles are strategically positioned around the turret and automatically spray cleaning liquid at high pressure in coordination with the Safe Deactivation process.

• Precision Cleaning: Effectively cleans hard-to-reach areas between the turret and punches, minimizing toxic residue.
• Process Efficiency: Cleaning is performed in a sealed state, reducing the need for heavy personal protective equipment (PPE) and shortening cleaning time.

3. High Productivity With Operational Flexibility

In addition to high containment performance, the PR-1500H delivers the productivity required for commercial-scale pharmaceutical manufacturing.

• Ultra-High Speed Output: Capable of producing up to 223,200 tablets per hour.
• Removable Turret Design: Turrets can be quickly detached and cleaned in a separate safe area.
• Intelligent Quality Control: Real-time weight monitoring system with Single Reject functionality.

4. Total Containment Line Integration & Process Flow

The PR-1500H is designed not only as a standalone tablet press but as part of a fully contained production line, ensuring a seamless flow from raw material to finished product.

Step-by-Step Flow Details:

• Step 1. Dust-Free Charging: Raw materials are securely transferred using an Alpha/Beta Valve system.
• Step 2. Contained Compression: Process occurs within the isolated turret zone.
• Step 3. Real-time Quality Check: Out-of-spec products are individually ejected via the Single Reject gate.
• Step 4. Enclosed Discharge: Tablets are transferred through an enclosed chute.
• Step 5. Secure Collection: Final products are collected in a sealed container.

Why PR-1500H?

• Designed for HPAPI Safety: Targeted turret zone containment.
• Integrated WIP with Safe Deactivation: Protects operators during cleaning.
• High Output, Proven Stability: Commercial-scale productivity.
• Flexible Tooling & Easy Changeover: Removable turret design.
• Total Containment Compatibility: Seamless integration.